Anti-C1q vasculitis, also called hypocomplementemic urticarial vasculitis syndrome (HUVS), is a rare small-vessel vasculitis linked to autoantibodies against C1q, a protein of the complement system. It typically presents with chronic hives (urticaria) that last more than 24 hours and leave bruising or skin discoloration. Other common features include joint pain, eye inflammation, and sometimes lung or kidney involvement. Low complement levels in the blood are characteristic. HUVS is considered a primary immune complex–mediated vasculitis in the CHCC 2012 classification, but it can overlap with systemic autoimmune diseases such as lupus.
In November, patients, caregivers, clinicians and researchers from more than a dozen European countries met in Prague for the 2025 European Vasculitis Patient Summit.
A landmark review in Nature Reviews Rheumatology calls for a new, integrated approach to ANCA-associated vasculitis.When diagnosis, classification, biomarkers and patient experience come together, care becomes truly personal — and outcomes improve.
Melbourne Februari 21-25 2026
The 22nd edition of this international workshop on vasculitis will take place from February 21 to 25, 2026, in Melbourne, Australia. Organized by the Australian and New Zealand Vasculitis Society (ANZVASC).